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Prevalence and clinical significance of Cryptosporidium infection in patients with hepatitis B virus-associated acute-on-chronic liver failure.

Yu Z, Li F, Zeng Z, Huang Z, Fan Z, Jin Y, Luo W, Xiang X, Deng Q.
Int J Infect Dis. 2011 Dec;15(12):e845-8. doi: 10.1016/j.ijid.2011.08.006. Epub 2011 Oct 12.


Department of Infectious Diseases, Nanshan Hospital, Guangdong Medical College, No. 89, Taoyuan Road, Nanshan District, Shenzhen 518052, China.



Patients with acute-on-chronic liver failure (ACLF) are often highly susceptible to microbial infection due to a depressed immune system. This study was carried out to investigate the prevalence and clinical significance of Cryptosporidium infection in patients with hepatitis B virus (HBV)-associated ACLF in Hunan Province, China.


Fecal samples from 218 patients with HBV-associated ACLF, 122 patients with chronic hepatitis B (CHB), and 140 children with diarrhea were collected; Cryptosporidium infection was detected by auramine-phenol staining, modified acid-fast staining, and the polymerase chain reaction. The clinical characteristics of this parasitic infection in Cryptosporidium-positive ACLF patients were further evaluated.


The prevalence of Cryptosporidium infection in the HBV-associated ACLF patients was 6.0% (13/218), which was markedly higher than that found in CHB patients (0.8%, 1/122) and in children with diarrhea (1.4%, 2/140). Although watery diarrhea was not seen in the 13 Cryptosporidium-positive ACLF patients, eight (61.5%) of them had diarrhea. Moreover, our investigation showed that Cryptosporidium infection was not associated with the severity of the disease in ACLF patients.


The prevalence of Cryptosporidium infection is high among patients with HBV-associated ACLF and might be a significant cause of diarrhea in this population.
Copyright © 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.


    • Total cases enrolled = 10516
    • Total centers across Asia = More than 95
    • Total manuscripts = More than 40
    • Total video conferences conducted = 98
    • Total abstract presented in conference by AARC group = More than 50

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