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Acute-on-chronic liver failure in chronic hepatitis B.

Seto WK, Lai CL, Yuen MF.
J Gastroenterol Hepatol. 2012 Apr;27(4):662-9. doi: 10.1111/j.1440-1746.2011.06971.x.

Source

Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.

Abstract

Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factors and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analog therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy.

ACHIEVMENTS

    • Total cases enrolled = 4279
    • Total centers across Asia = 50
    • Total manuscripts = 6
    • Total video conferences conducted = 37
    • Total abstract presented in conference by AARC group = 44